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SynFarsa is characterized, a synthetic circRNA-derived IRES-like element that promotes cap-independent translation in mouse and human cells and provides a circRNA-derived effector domain for targeted translational upregulation of an endogenous protein.
Background Autism spectrum disorder (ASD) shows a strong male bias (∼4:1). CHD8, a frequently mutated ASD gene, regulates neuronal development and Xist regulation in X-chromosome inactivation (XCI). However, its role in female neurodevelopment remains poorly understood due to the predominance of male-derived or sex-agn...
This work examines the physicochemical principles underlying RNA-mediated crowding, focusing on how sequence-driven multivalency, structural topology, and network connectivity govern molecular organization.
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