Author

G. Testa

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#gene editing Open access Sep 2026

Human-Specific Regulation of CHD2 Controls the Tempo of Cortical Development through Lysosomal Homeostasis

It is demonstrated that CHD2 dosage bidirectionally regulates lysosomal function and autophagosome flux to set the tempo of neuronal maturation, and that CHD2 and lysosomal homeostasis constitute a critical molecular axis regulating the pace of cortical development across evolution and disease.

O. Leonardi, E. Lewerissa, Davide Aprile et al. · bioRxiv · 3 citations

Open access Aug 2026

The human RNA-DNA interactome is cell type-specific and dynamic

The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.

A. Lambolez, P. Sahlén, Wenjing Kang et al. · bioRxiv · 0 citations