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Oct 2026

A natural compound derivative targeting HADHA disrupts mitochondrial homeostasis and suppresses renal cell carcinoma.

Metastatic renal cell carcinoma (RCC) remains a lethal malignancy, and therapeutic resistance to current targeted and immune-based therapies highlights the need for new treatment strategies. Here, we identify C18-epi-brasilibactin A (CBA) as a selective inhibitor of RCC. High-throughput screening of a compound library...

Ara Jo, Sanjeevram Dhandapani, Zi-Qin Wang et al. · 0 citations
#gene editing Oct 2026

BAHCC1 Drives Smooth Muscle Plasticity and Neointima via Epigenetic Repression.

BACKGROUND: Vascular smooth muscle cell (SMC) phenotypic plasticity drives neointimal hyperplasia (IH) and contributes to atherosclerosis. Epigenetic mechanisms have been implicated in SMC plasticity, but the roles of epigenetic reader proteins are poorly understood. BAHCC1 (bromo adjacent homology domain coiled-coil 1...

Run-Ze Tang, Yi-Tao Huang, T. Shirasu et al. · 0 citations

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