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Author

G. Yardımcı

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#gene editing Open access Sep 2026

Mutant ASXL1 Cooperates with MECOM and BRD4 to Drive Transcriptional Dysregulation in Human Hematopoiesis.

This work extensively characterized a CRISPR-engineered human hematopoietic stem and progenitor cell model of ASXL1 mutations, and is the first to functionally describe the mutant ASXL1 interactome in the context of human HSCs, identifying MECOM and BRD4 as actionable dependencies with therapeutic potential for ASXL1-m...

Madison L. Hall, Aliya Quintal, Sonia N. Acharya et al. · 0 citations
Open access Jul 2026

Robust and generalizable CNV detection for single-cell sequencing assays

RIDDLER stands out as a scalable, generalizable multi-modal method for accurate CNV detection, empowering studies aiming to link CNV dynamics to epigenetic alterations within the same cell, empowering studies aiming to link CNV dynamics to epigenetic alterations within the same cell.

Travis W Moore, H. Mohammed, Andrew C. Adey et al. · 0 citations

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