Proteolytic Activation of T Cell Engagers And Bispecific Proteins Using Modular Coiled-Coil Peptides.
Protease-responsive masked BiTEs using OKT3 and UCHT1 mAb clones are developed, that activate T cells only after exposure to tumor micro-environment-associated proteases and stimulate the T cell activation by their tumor-antigenic targets, and could be of broad utility towards helping constrain BiTE-mediated immune-act...