Open access
Oct 2026
A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies
PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies.
Z. Szilágyi, P. Michon, Carlos Pardo-Hernández et al.
· Life Science Alliance · 0 citations