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#gene editing Open access Sep 2026

Base editing-mediated induction of stop codons in HPV18 E6/E7 for cervical cancer therapy.

Persistent infection with high-risk human papillomaviruses (hrHPVs) is a primary driver of cervical carcinogenesis, with the viral oncogenes E6 and E7 playing pivotal roles. Conventional nuclease-based gene-editing strategies are limited by genome-wide off-target effects and genomic perturbations associated with double...

Yue Kang, Yi-Fan Wu, Bing-Ting Bao et al. · 0 citations
Open access Jul 2026

Integrating epigenetic and metabolic indicators for non-invasive endometrial cancer triage: a machine learning approach.

OBJECTIVE Abnormal uterine bleeding (AUB) is a primary symptom indicative of endometrial cancer (EC), yet its diagnosis still primarily relies on invasive biopsy. This study aimed to develop and validate a non-invasive, interpretable machine learning (ML) model integrating local epigenetic (exfoliated cell CDO1 methyla...

Xiaodan Mao, Xite Lin, Yashi Shi et al. · 0 citations

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