Author

Giovanni Maglia

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#protein folding Open access Oct 2026

Engineered MspA Nanopores for Real-Time Detection of Insulin, Its Pharmaceutical Analogues, and Degradation Products

Nanopore sensors have demonstrated single-molecule resolution for nucleic acids and small molecules, yet the discrimination and detection of folded proteins in complex biological matrices remains a challenge. Insulin is a demanding test case: it circulates in blood at picomolar concentrations, differs from clinically...

Sabine Straathof, Matthijs Tadema, Li-Xing Zhan et al. · ACS Nano · 0 citations

Aug 2026

Tunable DNA-Stabilized Bicelles as Nanoscale Membrane Mimetic Systems.

Membrane proteins are central to cellular function and constitute the majority of drug targets, yet their structural and functional characterization at the single-molecule level requires stabilization within a native-like lipid environment. Here, we introduce a robust and tunable DNA origami nanodisc that incorporates...

J. Gevers, K. Martens, Maarten Fauvart et al. · ACS Nano · 0 citations