Author

Giulia Palermo

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#gene editing Open access Oct 2026

Transposon end recognition and pairing by I-F3 CRISPR-associated transposase

To develop gene therapy tools based on CRISPR-associated transposons (CASTs), it is essential to define how transposon ends are recognized and paired during transposition. Transposon 7 (Tn7)–like transposons typically contain asymmetric left- and right-end sequences that flank and define DNA cargo. However, how the tra...

Vinh H. Truong, Darcie J. Miller, Shirin Fatma et al. · Science Advances · 0 citations

Sep 2026

Edge-Aware Graph Attention Networks for Interpreting Biophysical Mechanisms from Molecular Dynamics Simulations

This approach provides an interpretable AI strategy for uncovering the communication mechanisms that underlie folding, allostery, and long-range signal propagation in molecular machines, while also supporting AI-guided modulation of biomolecular function and rational protein engineering.

Mohd Ahsan, Chinmai Pindi, Giulia Palermo · bioRxiv · 0 citations