Author

Giuseppe Rizzo

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Open access Aug 2026

TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium

Myocardial infarction is a leading cause of death and disability worldwide. Ischemic injury leads to irreversible loss of cardiomyocytes, the contractile cells of the heart, and formation of a fibrotic scar. After infarction, macrophages massively infiltrate the heart and orchestrate the tissue repair process by removi...

Giuseppe Rizzo, Marie Piollet, T. Krammer et al. · bioRxiv · 0 citations

#gene editing Open access Oct 2026

Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis.

Using this mouse model, it is demonstrated that sFLT1 alone is sufficient for developmental vasculogenesis, whereas the specific loss of flFLT1 enhances reparative revascularization and angiogenesis and improves cardiac recovery after myocardial infarction.

M. Bundalo, Sandra Vorlová, Jessica Ulrich et al. · Cardiovascular Research · 0 citations