Author

Gonçalo Trindade

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Review Open access Sep 2026

Transmembrane lectins in cancer immunity: emerging drivers of myeloid-mediated immunosuppression

Immune evasion in cancer is sustained by coordinated interactions between malignant, stromal, and immune cells within the tumor microenvironment. Among these, myeloid populations are major regulators of immunosuppression, but the diverse signals that shape their functional states remain insufficiently integrated within...

Gonçalo Trindade, Angelina S. Palma, Catarina Brito · Frontiers in Immunology · 1 citation

Open access Sep 2026

Myeloid Lectin Profiling Identifies SYK as a Targetable Signaling Node for Remodeling Immunosuppressive Tumor-Associated Macrophages in Breast Cancer

Immunosuppressive tumor microenvironments (TMEs) are common in breast cancer (BC), where tumor-promoting myeloid-driven inflammation contributes to immune dysfunction and poor immunotherapy response. Lectins expressed by tumor-associated macrophages (TAMs) act as glycan-sensing immunoregulatory receptors driving immuno...

Gonçalo Trindade, G. Domenici, M. Pinto et al. · bioRxiv · 0 citations