Guanglei Chen

A single-cell study of transcription and RNA splicing in MDD and ALC

Potential mechanisms by which microbiota-accessible carbohydrates regulate hepatic lipid metabolism in MAFLD via the gut-liver axis

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic metabolic liver disorder, whose onset and progression are closely associated with dysregulated lipid metabolism, chronic inflammation, and intestinal microbial dysbiosis. The gut and liver are anatomically and functionally connected via...

Genomic structural equation modeling uncovers shared genetic architecture and comorbidity mechanisms of lung function decline.

Chronic respiratory diseases cause substantial global morbidity and mortality, yet the shared genetic architecture of pulmonary-function traits, exposure-related phenotypes, and cardiometabolic traits remains incompletely characterised. We applied genomic structural equation modelling to GWAS summary statistics for fou...

The role of lysine acylation in metabolic dysregulation and inflammatory responses within the hepatic immune microenvironment of MASLD

Metabolic dysfunction–associated steatotic liver disease (MASLD) is a chronic liver disorder characterized by metabolic abnormalities, persistent low-grade inflammation, and alterations in hepatic immune function. In addition to lipid accumulation and dysregulated energy metabolism, metabolism-associated post-translati...