Aug 2026
An epigenetic switch in β-cells links mitochondrial stress to inflammatory fate via HMGB1 acetylation.
A stress-responsive signalling network in which metabolic and mechanical cues are integrated at the epigenetic level to control the inflammatory fate of β-cells is unveiled, providing a new mechanistic framework for diabetic pathogenesis and a rationale for combinatorial therapeutic intervention.
Yao Cheng, Lu-Yao Wang, Xue Bai et al.
· Cell Death and Differentiati... · 0 citations