An epigenetic switch in β-cells links mitochondrial stress to inflammatory fate via HMGB1 acetylation.

Yao Cheng Lu-Yao Wang Xue Bai Guo-Qi Zhu Yinghua Xu Bin Wang Qiying Yi Guang-Neng Liao Jinglan Huang Dan Wang Sirong He

Aug 2026 · Cell Death and Differentiation · 0 citations · 32 references

Medicine

TL;DR

A stress-responsive signalling network in which metabolic and mechanical cues are integrated at the epigenetic level to control the inflammatory fate of β-cells is unveiled, providing a new mechanistic framework for diabetic pathogenesis and a rationale for combinatorial therapeutic intervention.

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