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Author

Guang-Rong Zheng

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#protein folding Oct 2026

Abstract C141: Race-dependent epigenetic restoration of acinar identity in normal human pancreatic 3D organoids

Since maintenance of acinar identity suppresses cellular plasticity and limits ADM, restoration of acinar gene expression represents a promising differentiation-based therapeutic strategy for early pancreatic cancer.

M. A. Siddique, Jin-Mai Jiang, Anrew A. Brock et al. · 0 citations
Sep 2026

A 2-in-1 Strategy for the Discovery of Compact HDAC8 Protac Degraders

A “2-in-1” PROTAC design strategy for developing more compact HDAC8 degraders by integrating the CRBN-recruiting ligand into the capping group of an HDAC8 warhead, thereby enabling a single structural motif to engage both HDAC8 and CRBN.

Yi Liu, Nikee Awasthee, Yufeng Xiao et al. · 0 citations

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