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Gunnar von Heijne

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#protein folding Open access Oct 2026

Buried Ion-Pairs Reshape Folding Pathways of Artificial Proteins

Ion-pairs are central charged motifs that control the biological function of several proteins. Yet, the physical principles linked to the formation of ion-pairs during protein folding remain poorly understood. Here, we show that buried ion-pairs of de novo-designed helical bundle proteins reshape the folding pathways b...

Jobst Liebau, Grant Kemp, Dirk Auman et al. · 0 citations

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