Leveraging Protein Dynamics for Selective Inhibition of Threonyl‐tRNA Synthetase by Obafluorin Analogs
The widespread emergence of antibiotic resistance necessitates the development of novel agents with unique mechanisms of action. Obafluorin (OB), a natural β-lactone antibiotic, is a covalent inhibitor of threonyl-tRNA synthetase (ThrRS), but the high conservation of the active site between prokaryote and eukaryote Thr...
Zilu Wang, Zhengxuan Zhang, Mingyu Xia et al.
· Angewandte Chemie · 0 citations