Coupling a developmental promoter to CRISPR interference for Wnt pathway regulation in human pluripotent stem cells
While directed differentiation of human pluripotent stem cells commonly relies on the timed delivery of extracellular factors, these uniform treatments often yield heterogeneous responses across cell populations. Linking intracellular gene regulation directly to an emerging developmental state offers a complementary st...
Gyuhyung Jin, S. Palecek
· bioRxiv · 0 citations