Author

H. Arai

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Open access Sep 2026

Dietary Variety as a Potential Modifier of Multidomain Intervention Effects on Gait Speed in Older Adults with Mild Cognitive Impairment: A Secondary Analysis of the J-MINT Trial.

BACKGROUND Multidomain lifestyle interventions benefit older adults, but individual responses vary considerably. Although nutritional counseling is a core component of these programs, whether baseline dietary patterns modify intervention effects remains unknown. In this exploratory secondary analysis of the J-MINT rand...

Masato Ogawa, T. Sugimoto, T. Sakurai et al. · Clinical Nutrition ESPEN · 0 citations

Open access Oct 2026

APOE4 allele modifies the effect of lifestyle interventions on cognition

The apolipoprotein E ε4 allele (APOE4) is the main genetic risk factor for incidence and earlier onset of dementia, and APOE4 carriers are thus considered a key target group for dementia risk reduction. APOE4 carriership also impacts the association between lifestyle and cognitive decline. Our meta-analysis inves...

J. Lehtisalo, Ari Solomon, E. Levälahti et al. · Communications Medicine · 0 citations

#protein folding Open access Oct 2026

Integration of blood‐based biomarkers and genomic variants identifies individuals with mild cognitive impairment who benefit from multidomain intervention

The findings suggest that BBMs, potentially in combination with genetic information, may help identify individuals with a more progressive AD‐related biological profile who may derive greater benefit from multidomain intervention.

Tetsuaki Kimura, A. Nakamura, T. Sugimoto et al. · Alzheimer's & Dementia · 0 citations