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Open access Sep 2026

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans

RNA interference (RNAi) is a widely conserved genome-defense mechanism that protects eukaryotes against viruses and transposable elements. We previously showed that RNAi loss can lead to hypermutation and antifungal drug resistance in the human fungal pathogen Cryptococcus neoformans, illuminating the potential clinica...

Jun Huang, Connor J. Larmore, Timothy C. Davenport et al. · 0 citations
#protein folding Open access Sep 2026

Data mining sheds light on a novel family of plant-associated negative-sense RNA viruses linked to lispiviruses

Large-scale mining of public transcriptomic datasets can reveal viral diversity that remains invisible to conventional virus-surveillance approaches, while increasingly powerful structure-prediction methods provide a complementary route to characterizing highly divergent viral proteins. Here, we combine sequence detect...

N. Bejerman, D. Huebert, R. Alvarez-Quinto et al. · 0 citations

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