Author

H. Dorison

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Open access Jul 2026

Machine Learning-Guided Engineering of High-Affinity Cross-Reactive Antibodies with Minimal Mutations

A Deep Mutational Scanning-coupled deep learning strategy to engineer potent cross-reactive antibodies with minimal sequence divergence that retained PD-1/PD-L1 blockade and demonstrated therapeutic activity in a mouse tumor model is developed.

H. Dorison, Anne-Laure Grindel, François Thenier et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Enhancing yeast folding capacity by genome editing unlocks quantitative and qualitative improvements in antibody surface display

This optimized yeast display platform enables more faithful translation of antibody biophysical features, supporting its application in antibody workflows, including selections based on biophysical properties.

E. Garcia-Calvo, H. Dorison, G. Mazón et al. · Microbial Cell Factories · 0 citations