Human hippocampus niche and circuit neurotypical and major depression pro�les
Proteomics and transcriptomics convergent dysregulations in MDD, point to lipid metabolism, neurogenesis, synaptogenesis, cell adhesion, cell adhesion, and plasticity.
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Proteomics and transcriptomics convergent dysregulations in MDD, point to lipid metabolism, neurogenesis, synaptogenesis, cell adhesion, cell adhesion, and plasticity.
A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.
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