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#gene editing Review Open access Sep 2026

The Asian perspective on xenotransplantation: bridging the organ gap through regional collaboration and tailored clinical protocols.

Xenotransplantation using genetically engineered porcine organs has emerged as a transformative strategy to address the critical organ shortage crisis in Asia, where low deceased donation rates and high disease burden create a persistent supply-demand gap. This review examines the Asian perspective on xenotransplantati...

Kun Wang, Xia-Yu Lei, Tao Li et al. · 0 citations
Review Open access Sep 2026

Cell and tissue xenotransplantation: clinical purpose determines translational strategy and therapeutic endpoints.

Solid organ xenotransplantation is moving into early clinical use, whereas living xenogeneic cells and tissues are being developed for distinct therapeutic tasks. Product-based discussions can obscure differences in required functional duration, immune exposure, consequences of product loss, and acceptable treatment bu...

H. Hara · 0 citations
Review Open access Aug 2026

Rethinking preclinical models for genetically engineered porcine red blood cell xenotransfusion

Genetically engineered porcine red blood cells (pRBCs) are emerging as a potential supplementary source of oxygen-carrying cells for transfusion medicine. Triple-knockout (TKO) pigs lacking major carbohydrate xenoantigens, including Gal, Neu5Gc, and Sd(a), have substantially reduced human antibody binding in vitro, and...

Xiayu Lei, H. Hara, Tao Li et al. · 0 citations

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