H. M. Kutlu

Ceranib-2 potentiates cisplatin activity under an experimental in vitro hipec-like model by inducing integrated stress and cell death pathways in ovarian cancer

This study aims to investigate whether the addition of Ceranib-2, an acid ceramidase inhibitor, could enhance the cytotoxic efficacy of cisplatin under hyperthermic conditions using an OVCAR-3 ovarian cancer cell model. The combination of cisplatin and ceranib-2, administered at a tolerable hyperthermic temperature o...

Synthesis, In Vitro Cytotoxic Evaluation, DFT Calculation and Molecular Docking for Novel Pyridine Derivative Platinum Complexes

Novel pyridine derivative platinium complexes, ‐bis(2,4‐dimethylpyridine)dichloroplatinum(II), [PtCl2L12], bis(2‐amino‐5‐ chloropyridine)dichloroplatinum(II), [PtCl2L22] and bis(3‐amino‐2‐chloropyridine)dichloroplatinum(II), [PtCl2L32]‐ were synthesized and characterized via FT‐IR, UV‐Vis, 1H‐NMR, 13C‐NMR techniques an...

Carmofur inhibits ovarian cancer cell proliferation, migration, and invasion via disrupting the YAP-1/TEAD pathway: in vitro and in silico approaches