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Author

H. Rudayni

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Open access Sep 2026

Enhanced antimicrobial effect of thyme oil nanoemulsion combined with Lactobacillus acidophilus La-5 against Listeria monocytogenes in laboratory-prepared soft cheese

The development of natural and sustainable preservation strategies is important for improving food safety, extending shelf life, and reducing reliance on synthetic additives in dairy products. This study evaluates the antimicrobial effectiveness of thyme oil nanoemulsion and Lactobacillus acidophilus La-5, individually...

M. Zeinhom, H. Rudayni, H. Alfassam et al. · 0 citations
Open access Aug 2026

Breaking the Myb–KIX Alliance: Structure‐Guided Discovery of Biaryl Hydroxy‐Naphthamides as Disruptors of the c‐Myb–CBP/p300 KIX Protein–Protein Interaction

3‐hydroxy‐2‐naphthamides are established as promising scaffolds for targeting the c‐Myb–CBP/p300 KIX interface and are supported as the most conformationally stable interfacial binders.

H. Alfassam, Emadeldin M. Kamel, Sarah I. Othman et al. · 0 citations
Aug 2026

Targeting the c-Myb-CBP/p300 KIX protein-protein interaction with quinone-methide triterpenes: In silico mechanistic insights and MST biochemical validation.

Tingenone is identified as a promising scaffold for the development of new c-Myb-CBP/p300 KIX PPI inhibitors, having produced the clearest signatures of interfacial weakening and the most favorable disruption metrics.

Emadeldin M. Kamel, H. Rudayni, A. A. Allam et al. · 0 citations
Open access Aug 2026

Structure‐Based Discovery of Fumiquinazolines as Skp2–Cks1 Protein–Protein Interaction Disruptors: Mechanistic Computational Insights and Experimental Validation

Findings identify Fumiquinazoline D as an early‐stage biochemical hit for disruption of the Skp2–Cks1 interaction and as a potential scaffold for further mechanistic validation and medicinal‐chemistry investigation.

Emadeldin M. Kamel, A. A. Allam, H. Rudayni et al. · 0 citations
Aug 2026

Structure-guided delineation of umbelliferyl phosphate-based disruptors of the c-Myb-CBP/p300 KIX protein-protein interaction.

The interaction between c-Myb and the CBP/p300 KIX domain is a critical transcriptional regulatory event and an attractive target for the development of candidate disruptors of the recombinant c-Myb-KIX interaction. In this study, we used an integrated computational and experimental strategy to identify new small molec...

Emadeldin M. Kamel, H. Rudayni, A. A. Allam et al. · 0 citations

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