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Structure-based discovery of diphenylpyrazines as disruptors of the Skp2–Cks1 protein–protein interaction: computational insights and biochemical validation

Emadeldin M. Kamel A. A. Allam H. Rudayni Sarah I. Othman Fahad M. Alshabrmi Faris F. Aba Alkhayl A. M. Lamsabhi
Aug 2026 · Journal of Computer-Aided Molecular Design · Vol 40 · 0 citations · 27 references
Medicine

TL;DR

Findings validate the diphenylpyrazine scaffold as a promising chemotype for Skp2–Cks1 inhibition and identify C3 as a strong lead for further optimization.

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