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Open access Aug 2026

De Novo Discovery of Nonstandard Thioisoindole-Bridged Bicyclic Peptides Targeting Traf2- and NCK-Interacting Kinase.

Macrocyclization strategies that generate conformationally constrained peptide scaffolds within nucleotide-encoded library screening platforms have significantly advanced the discovery of de novo bioactive peptides. We previously reported ribosomal synthesis of topologically defined thioisoindole-bridged bicyclic (TiB)...

Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada et al. · 0 citations
#protein folding Open access Sep 2026

In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores.

The inclusion of non-proteinogenic amino acids (npAAs) into proteins vastly expands their chemical repertoire and hence possible functional diversity. However, it remains challenging to obtain non-proteinogenic sequences that carry out a specific task. Here we develop a platform to discover functional non-standard prot...

Adam T. Beattie, Alexander A. Vinogradov, Chikako Okada et al. · 0 citations

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