Hailong Pei

Senescent Cell‐Derived Extracellular Vesicles in Therapy‐Induced Senescence: Immune Remodelling and Emerging Links to Mitochondrial Stress in Cancer

ABSTRACT Cancer therapy can induce cellular senescence and remodel the tumour microenvironment through the senescence‐associated secretory phenotype (SASP), including its membrane‐enclosed component, senescent cell‐derived extracellular vesicles (senEVs). This review summarizes senEV biogenesis, cargo‐dependent functio...

ATMLP regulates MDVs mediated inflammation induced by radiotherapy in lung cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide, and radiotherapy, a commonly used treatment for lung cancer, is associated with a variety of complications while treating cancer, among which radiotherapy-induced pneumonia is a common complication whose underlying mechanism remains unclear and requir...

Triglyceride enhancs NSCLC metastasis via lipid β-oxidation by RhoA-driven cytoskeletal remodeling in ECM-constrained microenvironments.