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Hanqun Cao

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#artificial intelligence Preprint Sep 2026

MinkowskiPE: Minkowski Positional Encoding for Spatiotemporal Perception

Modeling spatiotemporal coupling is a key challenge in building physical intelligence across scales, from microscopic to macroscopic. Existing models capture such structure broadly through physics-motivated dynamical formulations or learning-motivated architectures. The former provide stronger priors but may constrain...

Yu-Hao Li, Louie Hong Yao, Tian-Yi Shi et al. · 0 citations
Book Open access Aug 2026

The Forgetting-Learning Trade-off: Making Reinforcement Learning Work for Protein Language Models

Diagnostics reveal that RL on PLMs is governed by two reward properties: verifiability, whether the reward is a fixed environment or a learned surrogate vulnerable to distribution shift, and coverage, the fraction of sequence space giving an informative gradient.

Hanqun Cao, Hongrui Zhang, Junde Xu et al. · 0 citations
Book Open access Aug 2026

The Forgetting-Learning Trade-off: Making Reinforcement Learning Work for Protein Language Models

Reinforcement learning (RL) is increasingly applied to Protein Language Models (PLMs), yet its effectiveness varies across tasks, and standard metrics such as pass@k can rise even when the model's solvable problem set is shrinking. We introduce two capability-level diagnostics. The Expansion-Shrinkage Ratio (ESR) measu...

Hanqun Cao, Hongrui Zhang, Junde Xu et al. · 0 citations
#protein folding Preprint Aug 2026

AgentFold: Closed-Loop Agentic Search for Protein Folding Model Design

AgentFold is presented, a multi-agent framework that formulates folding-model development as a closed-loop search over executable code variants and improves the best lDDT by 7.5% over independent Codex proposals and outperforms a random-search control.

Ming-Quan Liu, Jiangyue Chen, Han-Qun Cao et al. · 0 citations

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