Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections.
We introduce a solid-phase synthesis platform for the rapid, modular, and scalable synthesis of the synthetic metallophore KO-NH2, which is readily recognized by bacterial siderophore transporters, but has optimized affinity for Ga3+ over Fe3+. Four synthetic protochelin (PC) analogues, KK-COOH, KO-NH2, KO-COOH, and OK...
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason et al.
· Angewandte Chemie · 0 citations