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Author

Hari Prasad

2 papers indexed here

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Aug 2026

Bridging LysoPD and MitoPD: Lysosomal pH Links Two Hallmarks of Parkinson's Disease

Genetic studies have increasingly de fi ned two major biological subtypes of Parkinson ’ s disease (PD): lysosomal PD (LysoPD), exempli fi ed by GBA1 , and mitochondrial PD (MitoPD), typi fi ed by PRKN and PINK1 .

Hari Prasad · 1 citation
Open access Sep 2026

Endosomal pH Triggers Amyloid β Oligomerization and Maladaptive Phenotypic Plasticity in Alzheimer’s Disease

Endosomal dysfunction is a presymptomatic hallmark of neurodegeneration. Recent evidence highlights dysregulation of endosomal pH as a central pathogenic hub in Alzheimer’s disease (AD); however, the mechanisms linking pH shifts to neurodegeneration remain incompletely defined. Here, we use a quantitative model of endo...

R. K. Meena, A. S. Duddu, M. Jolly et al. · 0 citations

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