Bridging LysoPD and MitoPD: Lysosomal pH Links Two Hallmarks of Parkinson's Disease
Medicine
Abstract
Genetic studies have increasingly de fi ned two major biological subtypes of Parkinson ’ s disease (PD): lysosomal PD (LysoPD), exempli fi ed by GBA1 , and mitochondrial PD (MitoPD), typi fi ed by PRKN and PINK1 .