Author

Harsha Raheja

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Aug 2026

Viral Protease Nsp5 Hijacks La Autoantigen to Orchestrate the Translation to Replication Transition in SARS-CoV-2

It is demonstrated that human La autoantigen (La protein) specifically binds to GCAC sequence near the initiator AUG within the 5’UTR of SARS-CoV-2 RNA promoting viral non-structural protein synthesis by cap independent translation, while suppressing replication early in infection.

Risabh Sahu, Harsha Raheja, S. N. Gagan Gaurav et al. · bioRxiv · 0 citations

Open access Jul 2026

Cap-specific second nucleotide ribose methylase CMTR2 is required for transcriptome transition during mammalian germline development

It is revealed that CMTR2 does not influence innate immune response in human cells and mouse tissues, but shapes gene expression during developmental transitions.

Harsha Raheja, Elena Delfino, Michaela Dohnálková et al. · bioRxiv · 0 citations