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Viral Protease Nsp5 Hijacks La Autoantigen to Orchestrate the Translation to Replication Transition in SARS-CoV-2

Risabh Sahu Harsha Raheja S. N. Gagan Gaurav Santu Paul Shree V. Sabari P. K. Ghosh Raju S. Rajmani Saumitra Das
Aug 2026 · bioRxiv · 0 citations · 1 references
Biology

TL;DR

It is demonstrated that human La autoantigen (La protein) specifically binds to GCAC sequence near the initiator AUG within the 5’UTR of SARS-CoV-2 RNA promoting viral non-structural protein synthesis by cap independent translation, while suppressing replication early in infection.

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