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Hauke Holthusen

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#protein folding Open access Sep 2026

Consequences of mitochondrial protein aggregation

Toxic protein aggregates can accumulate in the cytosol and within organelles of cells when protein quality control machinery fails. Here, we systematically analyzed the consequences of protein aggregation in mitochondria by targeting aggregation-prone proteins to the mitochondrial matrix in Saccharomyces cerevisiae and...

Hauke Holthusen · 0 citations
#protein folding Open access Sep 2026

Mitochondrial protein import couples proteostasis failure to mitochondrial permeabilization

It is established that mitochondrial protein import couples translation-associated proteotoxic stress to mitochondrial injury and regulation of import flux as a determinant of mitochondrial integrity during proteostasis failure.

Zhi-Qi Sun, Hauke Holthusen, Sara Berndl et al. · 0 citations

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