ABE-mediated dual targeting of TOX and ARHGEF1 synergistically enhances antitumor activity of tumor-infiltrating lymphocytes in PDAC
Tumor-infiltrating lymphocytes (TILs) represent a promising immunotherapeutic modality in solid tumors, yet their clinical efficacy in pancreatic ductal adenocarcinoma (PDAC) remains severely limited by inefficient expansion and functional exhaustion. TILs were isolated from pancreatic cancer surgical specimens and wer...
Xi Ma, Huihui Sun, Kejia Liu et al.
· Oncogenesis · 0 citations