Review
Open access
Aug 2026
From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits
Abstract Purinergic signaling represents an ancient intercellular communication system. Operating at the interface between bioenergetic metabolism and damage detection, extracellular purines such as adenosine 5′-triphosphate (ATP) and adenosine (ADO) are recruited into the nervous system for neurotransmission and homeo...
L. B. Marques, Allan de Carvalho, Raphael Luiz Lobo da Silva Souza et al.
· Bioscience Reports · 0 citations