Poison exon splicing in the human brain provides a new paradigm for understanding and targeting neurological disorders
Poison exons are highly conserved exons whose inclusion creates premature termination codons and triggers nonsense-mediated decay (NMD) of the mature transcript. Despite their important role in post-transcriptional regulation, poison exons remain poorly annotated due to the lack of systematic transcriptome-wide approac...
Paolo Pigini, Huilin Xu, Yan Ji et al.
· Genome biology · 0 citations