Targeting the gene encoding human T-cell leukemia virus type 1 basic zip factor via CRISPR/Cas9 potentially affects ATL cell survival
Herein, we investigated the role of the human T-cell leukemia virus type 1 (HTLV-1)-encoded regulatory factor, HTLV-1 basic zip factor (HBZ), in HTLV-1 infections and adult T-cell leukemia/lymphoma (ATL). We designed five synthetic guide RNAs (sgRNAs) targeting HBZ and introduced them into ATL cell lines in vitro using...
Yuki Hashikura, Misaki Izaki, Kazumi Umeki et al.
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