Triple-Target CRISPR Strategy to Block HIV Entry and Replication in Permissive Cells.
The combination knockout of CCR5, MOGS, and viral sequences profoundly reduces HIV-1 replication in an ex vivo cellular model, that is, HIV-1-infected peripheral blood mononuclear human cells, thus offering a pathway to launch further preclinical studies.
Z. Safaei, Anna Bellizzi, Hong Liu et al.
· Human Gene Therapy · 0 citations