Hong-Xia Wang

Advancing O-Glycosylation Analysis of Fc-Fusion Proteins at the Domain Level by HILIC-MS with Supercharging.

Fragment crystallizable (Fc)-fusion proteins are formed by the fusion of functional peptides or receptor extracellular domains (ECDs) with Fc. They are normally very heterogeneous with multiple N- and O-glycosylation sites and a high level of sialylation. Characterization of O-glycosylation in Fc-fusion proteins is imp...