Author

Hong-Yan Zhao

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Open access May 2026

Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects

The rapid expansion of human genomic data has revealed a large number of naturally occurring variants, creating a major challenge for functional annotation. The human metal transporter SLC39A8 (ZIP8) is a clinically important, promiscuous divalent metal transporter, yet most of its documented variants remain uncharacte...

Michael Nikolovski, Tian-Qi Wang, Aaron Sue et al. · bioRxiv · 0 citations

Open access Sep 2026

Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects

A workflow to functionally evaluate ZIP8 variants by integrating laser ablation inductively coupled plasma time-of-flight mass spectrometry with scaled-up cell-based transport assays is developed and provides new insights into the structure-function relationships of ZIP8.

Michael Nikolovski, Tian-Qi Wang, Aaron Sue et al. · Journal of Biological Chemis... · 0 citations

#protein folding Open access Sep 2026

Symmetry analysis and ancestral sequence reconstruction reveal a symmetrical translocation pathway and activity determinants of ZIP metal transporters

This study demonstrates that combining internal symmetry analysis and ASR for the ZIP family facilitates elucidation of the metal translocation mechanism and identification of subfamily‐specific features that regulate transport function.

Yao Zhang, Tian-Qi Wang, Hong-Yan Zhao et al. · Protein Science · 0 citations