Mitochondrial Quality Control as the Mechanistic Hinge of Inherited Cardiomyopathy: Convergent Pathobiology and Targeted Therapy
Inherited mitochondrial cardiomyopathies arise from pathogenic variants that disrupt oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin biogenesis, or mitochondrial dynamics and quality control. Although the causative genes are diverse—mtDNA mutations, nuclear respiratory-chain and assembly factors,...
Chung-Lin Lee, Chih‐Kuang Chuang, Ya-Hui Chang et al.
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