Hsing‐I Ho

Engineered Phenylalanine Ammonia Lyases Enable Biocatalytic Synthesis of a Non-Canonical Phenylalanine Derivative at Scale.

Phenylalanine ammonia lyases (PALs) are an enzyme class of high synthetic utility as they catalyze the synthesis of chiral non-canonical phenylalanine amino acids from readily available cinnamic acids using simple ammonia as the amine donor. However, the applications of PAL in chemical manufacturing have been rare due...