Chromosomal translocations involving nucleoporin (NUP) loci, such as NUP98 and NUP214, are recurrent in acute myeloid leukemia (AML). However, the intrinsic functions of wild-type nucleoporins in AML remain largely unknown. By screening the NUP family, we identified NUP214 as a frequently overexpressed gene and a criti...
This study provides the first in vivo evidence that Nat10-mediated ac4C modification sustains macrophage proliferation and attenuates colitis progression by stabilizing Mcm2 mRNA.
Jin-Song Wang, Tao Liu, Jia-Cheng Zhao et al.· Science China Life Sciences· 0 citations
It is demonstrated that colonic macrophage-mediated extracellular matrix (ECM) remodeling orchestrates enteric neuronal maturation and dictates colitis progression and the m6Am machinery is illuminated as a promising therapeutic target for preventing neuronal loss in IBD patients.
It is shown, by genomic deletion of PCIF1 specifically in T cells, that PCIF1 represses STAT1 translation via this important mRNA modification, and thereby preventing T cell activation and enforcing a naïve T cell phenotype.
Jian-Song Huang, Jing Zhou, Xiao Liu et al.· Nature Communications· 1 citation
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