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Author

Huan Li

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#protein folding Open access Oct 2026

The p53 pulse encoder counts by topological necessity: theory, evidence, and the molecular origin of the 5.5-hour clock

After DNA damage, p53 does not signal how much damage there is by how much p53 there is: single cells fire a series of pulses whose amplitude is dose-invariant and whose number grows with dose. Why the encoder works this way has been open since the pulses were discovered. We show that the answer is topological. Pulse-g...

Huan Li · 0 citations
#protein folding Open access Oct 2026

The p53 pulse encoder counts by topological necessity: theory, evidence, and the molecular origin of the 5.5-hour clock: v1.0.0 - split-edition release

After DNA damage, p53 does not signal how much damage there is by how much p53 there is: single cells fire a series of pulses whose amplitude is dose-invariant and whose number grows with dose. Why the encoder works this way has been open since the pulses were discovered. We show that the answer is topological. Pulse-g...

Huan Li · 0 citations
#explainable ai Open access Oct 2026

Neither substitutable for the other: non-commensurable contributions in human-machine collaboration

AI-assisted science increasingly asks who contributed what, and answers with a share: the machine did eighty percent, so the human did twenty. We argue that the shared scale is the problem. Under an observation protocol the state of the world is not a point but an equivalence class, and work on it divides into two oper...

Huan Li · 0 citations

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