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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Huan Zhong

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Open access Sep 2026

From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn’s disease

Background Acute pancreatitis (AP) and Crohn’s disease (CD) exhibit overlapping clinical presentations and an unexpectedly high rate of comorbidity. Whether this reflects shared genetic susceptibilities remains unclear. Methods We performed a cross-trait genome-wide association analysis leveraging European-ancestry sum...

Wen-Bin Xu, Ao-Cheng Ji, Lu Han et al. · 0 citations
Open access Sep 2026

Shared genetic architecture of smoking dependence and Crohn's disease: A cross-trait analysis of GWAS summary statistics

SD and CD showed measurable shared genetic susceptibility, with convergent evidence from pleiotropic loci, immune-inflammatory pathway enrichment, tissue-level associations, and spatial transcriptomic mapping.

Ao-Cheng Ji, Wen-Bin Xu, Hao Xiong et al. · 0 citations
Review Open access Jul 2026

Omics research in Parkinson’s disease: evolution, integrated analysis, pathogenic mechanisms, biomarkers, and therapeutic targets

This review focuses on the transition from single-omics to integrative multi-omics analysis, which helps overcome the constraints of individual omics strategies and provides a more systematic understanding of PD pathogenesis.

Ruizhe Cao, Xue Bai, Huan Zhong · 0 citations

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