Author

Huaxin Yu

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Open access Sep 2026

Sequential assembly in vivo of the bacteriophage P22 genome translocation channel

Bacteriophage P22 ejects four internal proteins into infected cells to assemble a channel for genome translocation across the cell envelope. However, how these proteins cooperate to build the trans-envelope channel remains enigmatic. Using in situ single-particle cryogenic electron microscopy, we determined near-atomic...

Hua-Xin Yu, Jian Yue, Taehyun Park et al. · bioRxiv · 0 citations

Open access Jul 2026

Near-atomic in situ architecture and membrane-coupled dynamics of the Vibrio cholerae sheathed flagellum

In-situ near-atomic structures of the sheathed flagellar motor within intact cells are determined, revealing how the distinctive architecture and dynamics of the sheathed flagellum support V. cholerae motility, environmental survival, and persistent colonization of the human gut.

Wang-Biao Guo, Jian Yue, Jin Hwan Park et al. · Nature Communications · 1 citation

#protein folding Aug 2026

The human papillomavirus L2 protein in the capsid is an ensemble of related structures poised to exit the virus particle

A structural model of L2 within the capsid is developed using cryo-EM single particle analysis of HPV16 pseudovirus capsids with and without the L2 protein combined with AlphaFold3 predictions and molecular dynamics simulations to develop a structural basis for understanding how L2 is organized in the capsid poised to...

Changin Oh, Huaxin Yu, Patrick M. Buckley et al. · bioRxiv · 0 citations