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Hugh Wilson

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#protein folding Sep 2026

High-resolution mapping of RNA structural maturation during Cas9 assembly with ABEL-FRET

This work explored how the guide RNA of CRISPR genome editing system folds and modulates its structural flexibility to carry out the roles required for each assembly state from its unbound apo form to the functional Cas9 RNP state for target DNA cleavage using ABEL-FRET spectroscopy.

Bok-Eum Choi, Hugh Wilson, Quan Wang · 0 citations

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