Author

Hui-Jun Cheng

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Open access Sep 2026

LncRNA OIP5‐AS1 Promotes Glomerular Mesangial Cell Senescence by Interacting With ELAVL1 to Upregulate HMGB1

Glomerular mesangial cell (GMC) senescence contributes to the progression of various age‐related kidney diseases. However, the molecular mechanisms driving GMC aging remain poorly understood. OIP5‐AS1, a long non‐coding RNA (lncRNA), has been implicated in cellular senescence in other systems, but its role in renal agi...

Zhi-Wei Wu, Na Xue, Hui-Jun Cheng et al. · Cell Biochemistry and Functi... · 0 citations

Open access Sep 2026

Comparative metabolomic and transcriptomic profiling of flavonoid diversity and antioxidant capacity in three Isatis species.

The study establishes a clear genotype-metabolite-phenotype-phenotype linkage, highlighting glycosylation as a key mechanism underlying flavonoid-driven antioxidant superiority in Isatis.

Rong Chen, Yan Qing, Xiao-Shan Geng et al. · Genomics · 0 citations

Open access Aug 2026

Network pharmacology and molecular simulation study on the multi-target gene regulatory mechanism of Isatis indigotica against hepatic inflammation

It is suggested that Isatis indigotica acts on HBV-associated hepatic inflammation through multi-target synergistic regulation of NF-κB and JAK-STAT signaling pathways, providing mechanistic insights and potential therapeutic targets for HBV management.

Xue-Ru Li, Yang Wang, Hui-Jun Cheng et al. · PLoS ONE · 0 citations